Functional identification of a neurocircuit regulating blood glucose.

  title={Functional identification of a neurocircuit regulating blood glucose.},
  author={Thomas H. Meek and Jarrell T. Nelson and Miles E. Matsen and Mauricio D. Dorfman and Stephan J. Guyenet and Vincent A Damian and Margaret B. Allison and Jarrad M. Scarlett and Hong Tu Nguyen and Joshua P. Thaler and David P Olson and Martin G Myers and Michael J. Schwartz and Gregory J. Morton},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={113 14},
Previous studies implicate the hypothalamic ventromedial nucleus (VMN) in glycemic control. Here, we report that selective inhibition of the subset of VMN neurons that express the transcription factor steroidogenic-factor 1 (VMN(SF1) neurons) blocks recovery from insulin-induced hypoglycemia whereas, conversely, activation of VMN(SF1) neurons causes… CONTINUE READING
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