Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids.

@article{Miyauchi2004FunctionalIO,
  title={Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids.},
  author={Seiji Miyauchi and Elangovan Gopal and You-jun Fei and Vadivel Ganapathy},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 14},
  pages={13293-6}
}
SLC5A8, a tumor suppressor gene down-regulated in human colon cancer, codes for a transporter in the Na(+)/glucose cotransporter gene family, but the definitive functional identity of the transporter protein is not known. Since this gene is expressed abundantly in the colon where short-chain fatty acids are generated by bacterial fermentation, we tested the hypothesis that it codes for a Na(+)-coupled transporter for these fatty acids. The coding region of SLC5A8 mRNA was amplified from human… CONTINUE READING