Functional hyperemia in the brain: hypothesis for astrocyte-derived vasodilator metabolites.

@article{Harder1998FunctionalHI,
  title={Functional hyperemia in the brain: hypothesis for astrocyte-derived vasodilator metabolites.},
  author={David R. Harder and Nabil J. Alkayed and A R Lange and Debebe Gebremedhin and Richard J. Roman},
  journal={Stroke},
  year={1998},
  volume={29 1},
  pages={229-34}
}
BACKGROUND Cerebral blood flow is tightly coupled to neuronal metabolic activity, a phenomenon referred to as functional hyperemia. The mechanisms underlying functional hyperemia in the brain have been extensively studied, but the link between neuronal activation and nutritive blood flow has yet to be defined. Recent investigations by our laboratory and others have identified a potential role for astrocytes as an intermediary cell type in this process. SUMMARY OF REVIEW This short review will… CONTINUE READING

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