Functional human mitochondrial DNA polymerase gamma forms a heterotrimer.

  title={Functional human mitochondrial DNA polymerase gamma forms a heterotrimer.},
  author={Elena Yakubovskaya and Zhixin Chen and Jos{\'e} A Carrodeguas and Caroline Kisker and Daniel F. Bogenhagen},
  journal={The Journal of biological chemistry},
  volume={281 1},
Mitochondrial DNA polymerase gamma (pol gamma) is responsible for replication and repair of mtDNA and is mutated in individuals with genetic disorders such as chronic external ophthalmoplegia and Alpers syndrome. pol gamma is also an adventitious target for toxic side effects of several antiviral compounds, and mutation of its proofreading exonuclease leads to accelerated aging in mouse models. We have used a variety of physical and functional approaches to study the interaction of the human… CONTINUE READING


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