Functional human endogenous retroviral LTR transcription start sites are located between the R and U5 regions.

@article{Kovalskaya2006FunctionalHE,
  title={Functional human endogenous retroviral LTR transcription start sites are located between the R and U5 regions.},
  author={Elena Kovalskaya and Anton Buzdin and Elena V Gogvadze and Tatyana V. Vinogradova and E. D. Sverdlov},
  journal={Virology},
  year={2006},
  volume={346 2},
  pages={373-8}
}
Human endogenous retroviruses (HERVs) occupy about 5% of human DNA and are thought to be remnants of ancient retroviral infections of human ancestors' germ cells. HERVs can modify expression of host cell genes through their cis-regulatory elements concentrated in their long terminal repeats (LTRs). Although numerous HERV-related RNAs were identified in the human transcriptome, for most of them, it remains unclear whether they are LTR-promoted or read-through products initiated from neighboring… CONTINUE READING

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