Functional homology among human and fission yeast Cdc14 phosphatases.

  title={Functional homology among human and fission yeast Cdc14 phosphatases.},
  author={Mar{\'i}a Dolores V{\'a}zquez-Novelle and Ver{\'o}nica Esteban and Avelino Bueno and Mar{\'i}a P Sacrist{\'a}n},
  journal={The Journal of biological chemistry},
  volume={280 32},
Budding and fission yeast Cdc14 homologues, a conserved family of serine-threonine phosphatases, play a role in the inactivation of mitotic cyclin-dependent kinases (CDKs) by molecularly distinct mechanisms. Saccharomyces cerevisiae Cdc14 protein phosphatase inactivates CDKs by promoting mitotic cyclin degradation and the accumulation of a CDK inhibitor to allow budding yeast cells to exit from mitosis. Schizosaccharomyces pombe Flp1 phosphatase down-regulates CDK/cyclin activity, controlling… CONTINUE READING

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