Functional homodimeric glycoprotein hormones: implications for hormone action and evolution.

@article{Moyle1998FunctionalHG,
  title={Functional homodimeric glycoprotein hormones: implications for hormone action and evolution.},
  author={William R. Moyle and Rebecca V. Myers and Yulei N. Wang and Yeosun Han and Weiying Lin and Gary L. Kelley and Paul H. Ehrlich and Shashidhar N. Rao and Michael P. Bernard},
  journal={Chemistry & biology},
  year={1998},
  volume={5 5},
  pages={
          241-54
        }
}
BACKGROUND Human chorionic gonadotropin (hCG), lutropin, follitropin, and thyrotropin act as alpha beta heterodimers to control reproduction and thyroid function. The alpha and beta subunits of these proteins are divided into three loops (alpha 1,alpha 2,alpha 3; beta 1,beta 2,beta 3) by cysteine knots and the heterodimer is stabilized by 20 beta-subunit residues wrapped around alpha 2 like a seatbelt. Understanding how these hormones interact with their receptors, a matter of considerable… CONTINUE READING

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