Functional heterogeneity of cancer-associated fibroblasts from human colon tumors shows specific prognostic gene expression signature.

@article{Herrera2013FunctionalHO,
  title={Functional heterogeneity of cancer-associated fibroblasts from human colon tumors shows specific prognostic gene expression signature.},
  author={Mercedes Zurita Herrera and Abul B. M. M. K. Islam and Alberto Herrera and Paloma Martin and Vanesa Garc{\'i}a and Javier Silva and Jos{\'e} Miguel Garc{\'i}a and Clara Salas and Ignacio Casal and Antonio Garc{\'i}a de Herreros and F{\'e}lix Bonilla and C. Javier Castro Pe{\~n}a},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2013},
  volume={19 21},
  pages={5914-26}
}
PURPOSE Cancer-associated fibroblasts (CAF) actively participate in reciprocal communication with tumor cells and with other cell types in the microenvironment, contributing to a tumor-permissive neighborhood and promoting tumor progression. The aim of this study is the characterization of how CAFs from primary human colon tumors promote migration of colon cancer cells. EXPERIMENTAL DESIGN Primary CAF cultures from 15 primary human colon tumors were established. Their enrichment in CAFs was… CONTINUE READING
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Identification of stromally expressed molecules in the Prognostic CAF Signature in Colon Cancer www.aacrjournals.org Clin Cancer Res

  • B Orr, AC Riddick, GD Stewart, RA Anderson, OE Franco, SW Hayward
  • on October
  • 2013
1 Excerpt

High expression of GOLPH3 in esophageal squamous cell carcinoma correlates with poor prognosis

  • JH Wang, XT Chen, ZS Wen, ZhengM, JM Deng, WangMZ
  • PLoS ONE 2012;7:e45622
  • 2012

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