Functional heterogeneity of cancer-associated fibroblasts from human colon tumors shows specific prognostic gene expression signature.


PURPOSE Cancer-associated fibroblasts (CAF) actively participate in reciprocal communication with tumor cells and with other cell types in the microenvironment, contributing to a tumor-permissive neighborhood and promoting tumor progression. The aim of this study is the characterization of how CAFs from primary human colon tumors promote migration of colon… (More)
DOI: 10.1158/1078-0432.CCR-13-0694