Functional heterogeneity of CD44 molecules in ovarian cancer cell lines.

  title={Functional heterogeneity of CD44 molecules in ovarian cancer cell lines.},
  author={Stephen A. Cannistra and B DeFranzo and Jonathan Niloff and C Ottensmeir},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={1 3},
We have previously shown that CD44 partly mediates ovarian cancer cell attachment to peritoneal mesothelium through recognition of mesothelial-associated hyaluronate. CD44 is a major receptor for hyaluronate and exists as a standard 90-180-kDa form (CD44H), as well as several higher molecular mass variant forms produced by alternative splicing. To determine whether functional differences exist between CD44H and its variants we have investigated the relationship between CD44 isoform expression… CONTINUE READING


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