Functional growth in tissue-engineered living, vascular grafts: follow-up at 100 weeks in a large animal model.

@article{Hoerstrup2006FunctionalGI,
  title={Functional growth in tissue-engineered living, vascular grafts: follow-up at 100 weeks in a large animal model.},
  author={Simon P Hoerstrup and Ian Cummings Mrcs and Mario Lachat and Frederick J. Schoen and Rolf Jenni and Sebastian Leschka and Stefan Neuenschwander and Doerthe Schmidt and A. Ajin Mol and Christina G{\"u}nter and Mathias G{\"o}ssi and Michele Genoni and Gregor Zund},
  journal={Circulation},
  year={2006},
  volume={114 1 Suppl},
  pages={I159-66}
}
BACKGROUND Living autologous vascular grafts with the capacity for regeneration and growth may overcome the limitations of contemporary artificial prostheses. Particularly in congenital cardiovascular surgery, there is an unmet medical need for growing replacement materials. Here we investigate growth capacity of tissue-engineered living pulmonary arteries in a growing lamb model. METHODS AND RESULTS Vascular grafts fabricated from biodegradable scaffolds (ID 18+/-l mm) were sequentially… CONTINUE READING
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