Functional group contribution of bile salt molecules to partitioning of a quaternary ammonium N,N-dimethyl derivative of propranolol.

@article{Lee1978FunctionalGC,
  title={Functional group contribution of bile salt molecules to partitioning of a quaternary ammonium N,N-dimethyl derivative of propranolol.},
  author={Hee Kyung Lee and Yie W. Chien and Ta-Tung Lin},
  journal={Journal of pharmaceutical sciences},
  year={1978},
  volume={67 6},
  pages={847-9}
}
A quaternary ammonium N,N-dimethyl derivative of propranolol was extracted from pH 7.4 phosphate buffer into 1-octanol as ion-pairs with 12 different bile salts. The binding number, n, and the extraction constant, Ke, were determined. To obtain group contribution values of the bile salt molecule from the ion-pair extraction data, multiple linear regression analysis by the Free-Wilson technique was applied. The results showed that the fundamental premise of the functional group's contribution to… CONTINUE READING
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