Functional glycosylation of human podoplanin: glycan structure of platelet aggregation-inducing factor.

@article{Kaneko2007FunctionalGO,
  title={Functional glycosylation of human podoplanin: glycan structure of platelet aggregation-inducing factor.},
  author={Mika Kato Kaneko and Yukinari Kato and Akihiko Kameyama and Hiromi Ito and Atsushi Kuno and Jun Hirabayashi and Tomomi Kubota and Koh Amano and Yasunori Chiba and Yasushi Hasegawa and Isoji Sasagawa and Kazuhiko Mishima and Hisashi Narimatsu},
  journal={FEBS letters},
  year={2007},
  volume={581 2},
  pages={331-6}
}
Podoplanin (Aggrus) is a mucin-type sialoglycoprotein that plays a key role in tumor cell-induced platelet aggregation. Podoplanin possesses a platelet aggregation-stimulating (PLAG) domain, and Thr52 in the PLAG domain of human podoplanin is important for its activity. Endogenous or recombinant human podoplanin were purified, and total glycosylation… CONTINUE READING