Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming.

@article{SamavarchiTehrani2010FunctionalGR,
  title={Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming.},
  author={Payman Samavarchi-Tehrani and Azadeh Golipour and Laurent David and Hoon-Ki Sung and Tobias A Beyer and Alessandro Datti and Knut Woltjen and Andras D Nagy and Jeffrey L. Wrana},
  journal={Cell stem cell},
  year={2010},
  volume={7 1},
  pages={64-77}
}
Somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) by expression of defined embryonic factors. However, little is known of the molecular mechanisms underlying the reprogramming process. Here we explore somatic cell reprogramming by exploiting a secondary mouse embryonic fibroblast model that forms iPSCs with high efficiency upon inducible expression of Oct4, Klf4, c-Myc, and Sox2. Temporal analysis of gene expression revealed that reprogramming is a multistep process… CONTINUE READING
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