Functional genomics in Drosophila models of human disease.

@article{Chen2012FunctionalGI,
  title={Functional genomics in Drosophila models of human disease.},
  author={Ko-Fan Chen and Damian C Crowther},
  journal={Briefings in functional genomics},
  year={2012},
  volume={11 5},
  pages={405-15}
}
It is occasionally observed that common sporadic diseases have rare familial counterparts in which mutations at a single locus result in a similar disorder exhibiting simple Mendelian inheritance. Such an observation is often sufficient justification for the creation of a disease model in the fly. Whether the system is based on the over-expression of a toxic variant of a human protein or requires the loss of function of an orthologous fly gene, the consequent phenotypes can be used to… CONTINUE READING

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