Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans

  title={Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans},
  author={Sanne P. Smeekens and Aylwin C. Y. Ng and Vinod Kumar and Melissa D. Johnson and Theo S Plantinga and Cleo C van Diemen and Peer Arts and Eug{\'e}ne T.P. Verwiel and Mark S Gresnigt and Karin Fransen and Suzanne van Sommeren and Marije Oosting and Shih-Chin Cheng and Leo A B Joosten and Alexander Hoischen and Bart Jan Kullberg and William K. Scott and John R Perfect and Jos W M van der Meer and Cisca Wijmenga and Mihai G Netea and Ramnik J. Xavier},
  booktitle={Nature communications},
Candida albicans is the most common human fungal pathogen causing mucosal and systemic infections. However, human antifungal immunity remains poorly defined. Here by integrating transcriptional analysis and functional genomics, we identified Candida-specific host defence mechanisms in humans. Candida induced significant expression of genes from the type I interferon pathway in human peripheral blood mononuclear cells. This unexpectedly prominent role of type I interferon pathway in anti-Candida… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 44 references

Cytokine gene polymorphisms and the outcome of invasive candidiasis: a prospective cohort study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America • 2012

Toll-like receptor 1 polymorphisms increase susceptibility to candidemia

Plantinga, S T.
J. Infect. Dis. 205, • 2012

Genetic variation in the dectin-1/CARD9 recognition pathway and susceptibility to candidemia

Rosentul, C D.
J. Infect. Dis. 204, • 2011

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