Functional genomics and target gene validation in experimental and human disease.

Abstract

In contrast to rare monogenic disorders related to mutations in distinct genes, frequent multifactorial diseases including complex neuronal disorders as well as neoplasms involve expression changes in a multitude of genes. The integration of data derived from human disease tissue and of animal models by data mining constitutes a recent approach to increase the pathogenetic significance of target genes. Functional validation by animal models represents a key step to develop new treatment pathways for common disorders.:

DOI: 10.1016/j.ddtec.2004.08.007

Cite this paper

@article{Schulte2004FunctionalGA, title={Functional genomics and target gene validation in experimental and human disease.}, author={Johannes Hubertus Schulte and Julika Pitsch and Albert J. Becker}, journal={Drug discovery today. Technologies}, year={2004}, volume={1 2}, pages={105-11} }