Functional genomic studies of tick cells in response to infection with the cattle pathogen, Anaplasma marginale.

@article{Fuente2007FunctionalGS,
  title={Functional genomic studies of tick cells in response to infection with the cattle pathogen, Anaplasma marginale.},
  author={Jos{\'e} de la Fuente and Edmour F. Blouin and Ra{\'u}l Manzano-Rom{\'a}n and Victoria Naranjo and Consuelo Almaz{\'a}n and Jos{\'e} Manuel P{\'e}rez de la Lastra and Zorica Zivkovic and Frans Jongejan and Katherine M. Kocan},
  journal={Genomics},
  year={2007},
  volume={90 6},
  pages={712-22}
}
The coevolution of ticks and the pathogens that they transmit has ensured their mutual survival. In these studies, we used a functional genomics approach to characterize tick genes regulated in response to Anaplasma marginale infection. Differentially regulated genes/proteins were identified by suppression-subtractive hybridization and differential in-gel electrophoresis analyses of cultured IDE8 tick cells infected with A. marginale. Nine of 17 of these genes were confirmed by real-time RT-PCR… CONTINUE READING

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