Functional genomic profiling of Aspergillus fumigatus biofilm reveals enhanced production of the mycotoxin gliotoxin.

@article{Bruns2010FunctionalGP,
  title={Functional genomic profiling of Aspergillus fumigatus biofilm reveals enhanced production of the mycotoxin gliotoxin.},
  author={Sandra Bruns and Marc J. Seidler and Daniela Albrecht and Stefanie Salvenmoser and Nicole Remme and Christian Hertweck and Axel A Brakhage and Olaf Kniemeyer and Frank-Michael C. M{\"u}ller},
  journal={Proteomics},
  year={2010},
  volume={10 17},
  pages={
          3097-107
        }
}
  • Sandra Bruns, Marc J. Seidler, +6 authors Frank-Michael C. Müller
  • Published in Proteomics 2010
  • Medicine, Biology
  • The opportunistic pathogenic mold Aspergillus fumigatus is an increasing cause of morbidity and mortality in immunocompromised and in part immunocompetent patients. A. fumigatus can grow in multicellular communities by the formation of a hyphal network encased in an extracellular matrix. Here, we describe the proteome and transcriptome of planktonic- and biofilm-grown A. fumigatus mycelium after 24 and 48 h. A biofilm- and time-dependent regulation of many proteins and genes of the primary… CONTINUE READING

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