Functional genomic analysis of oligodendrocyte differentiation.

  title={Functional genomic analysis of oligodendrocyte differentiation.},
  author={Jason C. Dugas and Yu Chuan Tai and Terence P. Speed and John Y. Ngai and Ben A Barres},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={26 43},
To better understand the molecular mechanisms governing oligodendrocyte (OL) differentiation, we have used gene profiling to quantitatively analyze gene expression in synchronously differentiating OLs generated from pure oligodendrocyte precursor cells in vitro. By comparing gene expression in these OLs to OLs generated in vivo, we discovered that the program of OL differentiation can progress normally in the absence of heterologous cell-cell interactions. In addition, we found that OL… CONTINUE READING
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