Functional genomic analysis of apoptotic DNA degradation in C. elegans.

  title={Functional genomic analysis of apoptotic DNA degradation in C. elegans.},
  author={Jay Zachary Parrish and Ding Xue},
  journal={Molecular cell},
  volume={11 4},
Chromosomal DNA degradation is critical for cell death execution and is a hallmark of apoptosis, yet little is known about how this process is executed. Using an RNAi-based functional genomic approach, we have identified seven additional cell death-related nucleases (crn genes), which along with two known nucleases (CPS-6 and NUC-1) comprise at least two independent pathways that contribute to cell killing, and likely signaling for phagocytosis, by degrading chromosomal DNA. Several crn genes… CONTINUE READING

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