Functional genomic analysis of apoptotic DNA degradation in C. elegans.

@article{Parrish2003FunctionalGA,
  title={Functional genomic analysis of apoptotic DNA degradation in C. elegans.},
  author={Jay Zachary Parrish and Ding Xue},
  journal={Molecular cell},
  year={2003},
  volume={11 4},
  pages={987-96}
}
Chromosomal DNA degradation is critical for cell death execution and is a hallmark of apoptosis, yet little is known about how this process is executed. Using an RNAi-based functional genomic approach, we have identified seven additional cell death-related nucleases (crn genes), which along with two known nucleases (CPS-6 and NUC-1) comprise at least two independent pathways that contribute to cell killing, and likely signaling for phagocytosis, by degrading chromosomal DNA. Several crn genes… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 63 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 55 references

NUC-1, a Caeno

Y. C. Wu, G. M. Stanfield, H. R. Horvitz
2000
View 11 Excerpts
Highly Influenced

13 , of Caenorhabditis elegans

D. J. Hoeppner, M. O. Hengartner, R. Schnabel
Philos . Trans . R . Soc . Lond . B Biol . Sci . • 2001
View 1 Excerpt
Highly Influenced

Phagocytosis procaspase9

P. W. Reddien, S. Cameron, H. R. Horvitz
J . Biol . Chem . Nature • 2001
View 1 Excerpt
Highly Influenced

Apoptotic DNA fragmentation and tissue homeostasis.

Trends in cell biology • 2002
View 3 Excerpts

Comprehen - DNase 1deficient mice

Z. Zhou, L. J. Licklider, S. P. Gygi, R. Reed
Nat . Genet . • 2002

The 3' end formation in small RNAs.

Gene expression • 2002
View 2 Excerpts

Similar Papers

Loading similar papers…