Functional genome annotation through phylogenomic mapping

  title={Functional genome annotation through phylogenomic mapping},
  author={Balaji S. Srinivasan and Nora B. Caberoy and Garret Suen and Rion G Taylor and Radhika Choksi Shah and Farah K. Tengra and Barry S. Goldman and Anthony G. Garza and Roy D. Welch},
  journal={Nature Biotechnology},
Accurate determination of functional interactions among proteins at the genome level remains a challenge for genomic research. Here we introduce a genome-scale approach to functional protein annotation—phylogenomic mapping—that requires only sequence data, can be applied equally well to both finished and unfinished genomes, and can be extended beyond single genomes to annotate multiple genomes simultaneously. We have developed and applied it to more than 200 sequenced bacterial genomes… CONTINUE READING

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