Functional foods, herbs and nutraceuticals: towards biochemical mechanisms of healthy aging

@article{Ferrari2004FunctionalFH,
  title={Functional foods, herbs and nutraceuticals: towards biochemical mechanisms of healthy aging},
  author={Carlos K. B. Ferrari},
  journal={Biogerontology},
  year={2004},
  volume={5},
  pages={275-289}
}
Aging is associated with mitochondrial dysfunctions, which trigger membrane leakage, release of reactive species from oxygen and nitrogen and subsequent induction of peroxidative reactions that result in biomolecules' damaging and releasing of metals with amplification of free radicals discharge. Free radicals induce neuronal cell death increasing tissue loss, which could be associated with memory detriment. These pathological events are involved in cardiovascular, neurodegenerative and… 

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References

SHOWING 1-10 OF 179 REFERENCES

Mechanisms of action of antioxidants as exemplified in vegetables, tomatoes and tea.

  • J. Weisburger
  • Chemistry, Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1999

Oxidants, antioxidants, and the degenerative diseases of aging.

TLDR
It is argued that this damage to DNA, protein, and lipid is a major contributor to aging and to degenerative diseases of aging such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts.

Establishing the significance and optimal intake of dietary antioxidants: the biomarker concept.

TLDR
The use of biomarkers provides a logical scientific basis for major intervention trials of antioxidants; such trials will, in turn, eventually validate or disprove the biomarker concept.

Food antioxidants and phytochemicals: present and future perspectives

The relatively high concentration of phenolic flavonoids in wines, grapes, green tea, and berry extracts contributes powerful antioxidant properties that may be beneficial by reducing oxidative

Plasma antioxidants and longevity: a study on healthy centenarians.

Melatonin Reduces Oxidant Damage and Promotes Mitochondrial Respiration

TLDR
Recent observations documenting melatonin's ability to stimulate electron transport and ATP production in the inner‐mitochondrial membrane also has relevance for melatonin as an agent that could alter processes of aging.

The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties.

  • B. MoosmannC. Behl
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1999
TLDR
The results call into question the idea of a general correlation between the intended pharmacological effects of estrogens and phenolic compounds and their effect on estrogen receptor-dependent pathways and may open the door toward the rational design of neuroprotective antioxidants with decreased hormonal side effects.

Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models: modulatory effects of phytochemicals.

TLDR
The aim of the study was to determine if flavonoids could protect against H2O2-induced DNA damage, as measured by the comet assay, in Caco-2 and HepG2 cells, and illustrate the use of cellular models to study oxysterol-induced toxicity.

Alterations in oxidative stress scavenger system in aging rat brain and lymphocytes

TLDR
Lymphocytes and brain showed a parallel pattern of age-related alterations in the free radical scavenger system components, which may help to develop therapeutic means to cure not only elderly but also individuals suffering from certain organic or psychiatric disorders.
...