Functional foods, herbs and nutraceuticals: towards biochemical mechanisms of healthy aging

  title={Functional foods, herbs and nutraceuticals: towards biochemical mechanisms of healthy aging},
  author={Carlos K. B. Ferrari},
Aging is associated with mitochondrial dysfunctions, which trigger membrane leakage, release of reactive species from oxygen and nitrogen and subsequent induction of peroxidative reactions that result in biomolecules' damaging and releasing of metals with amplification of free radicals discharge. Free radicals induce neuronal cell death increasing tissue loss, which could be associated with memory detriment. These pathological events are involved in cardiovascular, neurodegenerative and… 

Anti-aging potential of tree nuts with a focus on the phytochemical composition, molecular mechanisms and thermal stability of major bioactive compounds.

The consumption of tree nuts has been scientifically proven to improve lifespan and healthspan and should be a part of a healthy diet in the elderly.

Oxidative stress—implications, source and its prevention

These phytochemicals, therefore, are most appropriate in combating oxidative stress-related disorders due to their tendency to exert better protective effect without having any distinct side effect.

Dietary Antioxidant and Oxidative Stress: Interaction between Vitamins and Genetics

The elucidation of interaction between genetic variations and antioxidant status may have important implications for public health through the identification of individuals and populations who could benefit from dietary intervention and supplementation with antioxidants.

Flavonoid-rich foods (FRF): A promising nutraceutical approach against lifespan-shortening diseases

In this review, a comprehensive overview of the FRF for their potential role against lifespan-shortening complications, i.e., CVD, cancer, and diabetes is presented and the future perspective and dietary guidelines to reduce the fatal disease burden in urban populations are drawn.

Neuroprotective Herbs and Foods from Different Traditional Medicines and Diets

Plant secondary metabolites include an array of bioactive constituents form both medicinal and food plants able to improve human health, protecting against the chronic degenerative disorders mainly seen in Western industrialized countries, such as cancer, cardiovascular and neurodegenerative diseases.

Total Antioxidant Capacity: a biomarker in biomedical and nutritional studies

In many different pathophysiological conditions (heart and vascular diseases, diabetes mellitus, neurological and psychiatric disorders, renal disorders and lung diseases), TAC could be a reliable biomarker of diagnostics and prognostics, although several cautions for its use should be carefully done.


This review aims to emphasize the therapeutic properties of all types of foods like cereals and pulses, fruits and vegetables, dairy products, tea etc. which form a part of routine diet.

Mitochondria as a Target in the Therapeutic Properties of Curcumin

Some of the most recent findings of curcumin properties that suggest a close relationship of this antioxidant with the mitochondrial function are focused on.



Mechanisms of action of antioxidants as exemplified in vegetables, tomatoes and tea.

  • J. Weisburger
  • Chemistry, Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1999

Oxidants, antioxidants, and the degenerative diseases of aging.

It is argued that this damage to DNA, protein, and lipid is a major contributor to aging and to degenerative diseases of aging such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts.

Establishing the significance and optimal intake of dietary antioxidants: the biomarker concept.

The use of biomarkers provides a logical scientific basis for major intervention trials of antioxidants; such trials will, in turn, eventually validate or disprove the biomarker concept.

Food antioxidants and phytochemicals: present and future perspectives

The relatively high concentration of phenolic flavonoids in wines, grapes, green tea, and berry extracts contributes powerful antioxidant properties that may be beneficial by reducing oxidative

Plasma antioxidants and longevity: a study on healthy centenarians.

Melatonin Reduces Oxidant Damage and Promotes Mitochondrial Respiration

Recent observations documenting melatonin's ability to stimulate electron transport and ATP production in the inner‐mitochondrial membrane also has relevance for melatonin as an agent that could alter processes of aging.

The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties.

  • B. MoosmannC. Behl
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1999
The results call into question the idea of a general correlation between the intended pharmacological effects of estrogens and phenolic compounds and their effect on estrogen receptor-dependent pathways and may open the door toward the rational design of neuroprotective antioxidants with decreased hormonal side effects.

Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models: modulatory effects of phytochemicals.

The aim of the study was to determine if flavonoids could protect against H2O2-induced DNA damage, as measured by the comet assay, in Caco-2 and HepG2 cells, and illustrate the use of cellular models to study oxysterol-induced toxicity.

Alterations in oxidative stress scavenger system in aging rat brain and lymphocytes

Lymphocytes and brain showed a parallel pattern of age-related alterations in the free radical scavenger system components, which may help to develop therapeutic means to cure not only elderly but also individuals suffering from certain organic or psychiatric disorders.