Functional expression of the voltage-gated Na⁺-channel Nav1.7 is necessary for EGF-mediated invasion in human non-small cell lung cancer cells.

Abstract

Various ion channels are expressed in human cancers where they are intimately involved in proliferation, angiogenesis, invasion and metastasis. Expression of functional voltage-gated Na(+) channels (Nav) is implicated in the metastatic potential of breast, prostate, lung and colon cancer cells. However, the cellular mechanisms that regulate Nav expression… (More)
DOI: 10.1242/jcs.130013

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@article{Campbell2013FunctionalEO, title={Functional expression of the voltage-gated Na⁺-channel Nav1.7 is necessary for EGF-mediated invasion in human non-small cell lung cancer cells.}, author={Thomas Mark Campbell and Martin J Main and Elizabeth Moran Fitzgerald}, journal={Journal of cell science}, year={2013}, volume={126 Pt 21}, pages={4939-49} }