Functional expression of the rat pancreatic islet glucose-dependent insulinotropic polypeptide receptor: ligand binding and intracellular signaling properties.

@article{Wheeler1995FunctionalEO,
  title={Functional expression of the rat pancreatic islet glucose-dependent insulinotropic polypeptide receptor: ligand binding and intracellular signaling properties.},
  author={Michael B Wheeler and Richard Wayne Gelling and Christopher H. S. McIntosh and J. Georgiou and John Canvin Brown and Raymond A. Pederson},
  journal={Endocrinology},
  year={1995},
  volume={136 10},
  pages={
          4629-39
        }
}
Incretins are endogenous peptides released from the gastrointestinal tract into the circulation during a meal that potentiate glucose-stimulated insulin secretion. At present, there are two established incretins: glucose-dependent insulinotropic polypeptide (GIP) and the truncated glucagon-like peptides (tGLPs), which are now being investigated for use in the treatment of diabetes mellitus. In the present study we cloned a rat islet GIP receptor complementary DNA (GIP-R1) to answer several… CONTINUE READING

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