Functional expression of murine multidrug resistance in Xenopus laevis oocytes.

@article{Castillo1990FunctionalEO,
  title={Functional expression of murine multidrug resistance in Xenopus laevis oocytes.},
  author={G R Castillo and Juan Vera and Chuan Ping Yang and Susan Band Horwitz and O. M. Rosen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 12},
  pages={4737-41}
}
The development of multidrug resistance (MDR) is associated with the overproduction of a plasma membrane glycoprotein, P glycoprotein. Here we report the functional expression of a member of the murine mdr family of proteins and show that Xenopus oocytes injected with RNA encoding the mouse mdr1b P glycoprotein develop a MDR-like phenotype. Immunological analysis indicated that oocytes injected with the mdr1b RNA synthesized a protein with the size and immunological characteristics of the mouse… CONTINUE READING