Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo.

@article{Willnow1995FunctionalEO,
  title={Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo.},
  author={Thomas E. Willnow and Scott A. Armstrong and Robert Hammer and Joachim Herz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 10},
  pages={4537-41}
}
The 39-kDa receptor-associated protein (RAP) associates with the multifunctional low density lipoprotein (LDL) receptor-related protein (LRP) and thereby prevents the binding of all known ligands, including alpha 2-macroglobulin and chylomicron remnants. RAP is predominantly localized in the endoplasmic reticulum, raising the possibility that it functions as a chaperone or escort protein in the biosynthesis or intracellular transport of LRP. Here we have used gene targeting to show that RAP… CONTINUE READING
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