Functional expression of human cytochrome P450 enzymes in Escherichia coli.

@article{Yun2006FunctionalEO,
  title={Functional expression of human cytochrome P450 enzymes in Escherichia coli.},
  author={Chul-Ho Yun and Sung-Kun Yim and Dong-Hyun Kim and Taeho Ahn},
  journal={Current drug metabolism},
  year={2006},
  volume={7 4},
  pages={411-29}
}
Knowledge regarding cytochrome P450 (P450) is crucial to the fields of drug therapy and drug development, as well as in our understanding of the mechanisms underlying the metabolic activation of potentially toxic and carcinogenic compounds. Escherichia coli is the most extensively utilized host in the production of recombinant human P450 enzymes. However, the recovery of substantial yields of functionally active P450 proteins remains problematic. Mammalian P450 protein was first expressed in… CONTINUE READING

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