Functional expression of a recombinant unitary glutamate receptor from Xenopus, which contains N-methyl-D-aspartate (NMDA) and non-NMDA receptor subunits.

@article{Soloviev1996FunctionalEO,
  title={Functional expression of a recombinant unitary glutamate receptor from Xenopus, which contains N-methyl-D-aspartate (NMDA) and non-NMDA receptor subunits.},
  author={M. M. Soloviev and Matt J Brierley and Zi Yun Shao and Ian R. Mellor and Tatyana M Volkova and Ritu Kamboj and Hirohisa Ishimaru and H. L. Sudan and James Harris and R L Foldes and Eugene V. Grishin and Peter N. R. Usherwood and Eric A. Barnard},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 51},
  pages={32572-9}
}
A cDNA encoding a 100-kDa subunit (XenNR1) of the N-methyl-D-aspartate (NMDA) glutamate receptor type has been cloned from Xenopus central nervous system. When XenNR1 is coexpressed in a mammalian cell line with a recently cloned 51-kDa non-NMDA receptor subunit (XenU1), also from Xenopus, it forms a functional unitary receptor exhibiting the pharmacological properties characteristic of both NMDA and non-NMDA receptors. Firstly, XenU1 can replace NR2 subunits, in complementing XenNR1 to… CONTINUE READING

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