Functional expression of a GFP-tagged Kv1.5 alpha-subunit in mouse ventricle.

  title={Functional expression of a GFP-tagged Kv1.5 alpha-subunit in mouse ventricle.},
  author={H. Harold Li and Weinong Guo and Hao Xu and Rebecca Hood and Alvin Benedict and Jeanne M Nerbonne},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={281 5},
The experiments here were undertaken to determine the feasibility of increasing the cell surface expression of voltage-gated ion channels in cardiac cells in vivo and to explore the functional consequences of ectopic channel expression. Transgenic mice expressing a green fluorescent protein (GFP)-tagged, voltage-gated K+ (Kv) channel alpha-subunit, Kv1.5-GFP, driven by the cardiac-specific alpha-MHC promoter, were generated. In recent studies, Kv1.5 has been shown to encode the micromolar 4… CONTINUE READING


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