Functional expression of TRPV channels in T cells and their implications in immune regulation.

@article{Majhi2015FunctionalEO,
  title={Functional expression of TRPV channels in T cells and their implications in immune regulation.},
  author={Rakesh Kumar Majhi and Subhransu Sekhar Sahoo and Manoj Kumar Yadav and Belluru M. Pratheek and Subhasis Chattopadhyay and Chandan Goswami},
  journal={The FEBS journal},
  year={2015},
  volume={282 14},
  pages={2661-81}
}
The importance of Ca(2+) signalling and temperature in the context of T cell activation is well known. However, the molecular identities of key players involved in such critical regulations are still unknown. In this work we explored the endogenous expression of transient receptor potential vanilloid (TRPV) channels, a group of thermosensitive and non-selective cation channels, in T cells. Using flow cytometry and confocal microscopy, we demonstrate that members belonging to the TRPV subfamily… CONTINUE READING
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