Functional expression of CD40 antigen on human epidermal Langerhans cells.

@article{PguetNavarro1995FunctionalEO,
  title={Functional expression of CD40 antigen on human epidermal Langerhans cells.},
  author={Josette P{\'e}guet-Navarro and Catherine Dalbiez-Gauthier and Fr{\'e}d{\'e}rique Marie Rattis and Cees van Kooten and Jacques Banchereau and Daniel R Schmitt},
  journal={Journal of immunology},
  year={1995},
  volume={155 9},
  pages={4241-7}
}
It is now well established that interactions of CD40 on the B cells, along with its ligand (CD40-L) on the T cells, regulate B cell proliferation and differentiation. However, the functional significance of CD40 expression on cells known for most efficient Ag-presenting function, i.e., dendritic cells, is not so clear. In this study, we demonstrate that CD40 is expressed on human dendritic Langerhans cells (LC) freshly isolated from epidermis. Using CD40-L transfected cells, CD40 triggering was… CONTINUE READING

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