Functional expression of B7H1 on retinal pigment epithelial cells.

@article{Usui2008FunctionalEO,
  title={Functional expression of B7H1 on retinal pigment epithelial cells.},
  author={Yoshihiko Usui and Yoko Okunuki and Takaaki Hattori and Takeshi Kezuka and Hiroshi Keino and Nobuyuki Ebihara and Sunao Sugita and Masahiko Usui and Hiroshi Wako Goto and Masaru Takeuchi},
  journal={Experimental eye research},
  year={2008},
  volume={86 1},
  pages={
          52-9
        }
}
The interaction of programmed death-1 (PD-1) expressed on T cells with its ligands B7H1 (PDL1) and B7DC (PDL2) is known to be a mechanism of T cell inhibition. In the present study, we examined whether human or murine retinal pigment epithelial (RPE) cells express B7H1 and B7DC, and if so, whether these molecules expressed on RPE cells play an inhibitory role via interaction with T cells. The transcriptional levels and surface expression of B7H1 and B7DC on human RPE cell line (ARPE-19), RPE… CONTINUE READING
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