Functional expression and subcellular localization of an anion exchanger cloned from choroid plexus.

@article{Lindsey1990FunctionalEA,
  title={Functional expression and subcellular localization of an anion exchanger cloned from choroid plexus.},
  author={Amber Lindsey and Katja Susanne Annika Ilse Margret Schneider and Donna M. Simmons and Rudi A. Baron and Beth S. M. Lee and Ron R. Kopito},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 14},
  pages={5278-82}
}
We have isolated rat brain cDNA clones encoding AE2, a homologue of the erythrocyte anion exchanger, band 3 (AE1). Immunocytochemistry and in situ hybridization reveal that, in brain, AE2 expression is restricted to the basolateral membrane of the choroid plexus epithelium. Expression of a full-length mouse AE2 cDNA in COS-7 cells resulted in chloride- and bicarbonate-dependent alterations in intracellular pH, demonstrating that AE2 is a Cl/HCO3 exchanger. Cation replacement studies indicate… CONTINUE READING
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