Functional evidence of inverse agonism in vascular smooth muscle.

  title={Functional evidence of inverse agonism in vascular smooth muscle.},
  author={Mar{\'i}a Antonia Noguera and Mar{\'i}a Dolores Ivorra and Pilar D'Ocon},
  journal={British journal of pharmacology},
  volume={119 1},
1. In the present study, depletion of internal Ca2+ stores sensitive to noradrenaline (1 microM) in rat aorta, is the signal for the entry of extracellular Ca2+, not only to refill the stores but also, in our experimental conditions, to activate the contractile proteins. This induces an increase in the resting tone that constitutes, the first functional evidence of this Ca2+ entry. 2. The fact that methoxamine (100 microM) reproduces the same processes as noradrenaline but clonidine (1 microM… CONTINUE READING


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