Functional evidence for retinoid X receptor (RXR) as a nonsilent partner in the thyroid hormone receptor/RXR heterodimer.

@article{Li2002FunctionalEF,
  title={Functional evidence for retinoid X receptor (RXR) as a nonsilent partner in the thyroid hormone receptor/RXR heterodimer.},
  author={Dangsheng Li and Tong Li and Fang Wang and Heather Tian and Herbert H. Samuels},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 16},
  pages={5782-92}
}
Many members of the thyroid hormone/retinoid receptor subfamily (type II nuclear receptors) function as heterodimers with the retinoid X receptor (RXR). In heterodimers which are referred to as permissive, such as peroxisome proliferator activated receptor/RXR, both partners can bind cognate ligands and elicit ligand-dependent transactivation. In contrast… CONTINUE READING