Functional evidence for presence of lipid rafts in erythrocyte membranes: Gsalpha in rafts is essential for signal transduction.

@article{Kamata2008FunctionalEF,
  title={Functional evidence for presence of lipid rafts in erythrocyte membranes: Gsalpha in rafts is essential for signal transduction.},
  author={Kotoe Kamata and Sumie Manno and Makoto Ozaki and Yuichi Takakuwa},
  journal={American journal of hematology},
  year={2008},
  volume={83 5},
  pages={371-5}
}
Membrane microdomains enriched in cholesterol and sphingolipids and containing specific membrane proteins are designated as lipid rafts. Lipid rafts have been implicated in cell signaling pathways in various cell types. Heterotrimeric guanine nucleotide-binding protein (Gsalpha) has been shown to be a raft component of erythrocytes and has been implicated in cell signaling. Rafts are isolated as detergent-resistant microdomains (DRMs) for biochemical analysis. Cholesterol depletion is widely… CONTINUE READING
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