Functional evidence for presence of PEPT2 in rat choroid plexus: studies with glycylsarcosine.

@article{Teuscher2000FunctionalEF,
  title={Functional evidence for presence of PEPT2 in rat choroid plexus: studies with glycylsarcosine.},
  author={Nathan S. Teuscher and Alexander Novotny and Richard F. Keep and David E Smith},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2000},
  volume={294 2},
  pages={494-9}
}
PEPT2 expression has been established in brain and, in particular, mRNA transcripts and PEPT2 protein have been identified in choroid plexus. However, there is little evidence for the functional presence of this peptide transporter in choroid plexus tissue. In this study, we examined the in vitro uptake of a model dipeptide, glycylsarcosine (GlySar), with whole tissue rat choroid plexus in artificial cerebrospinal fluid. Our findings are consistent with the known transport properties of PEPT2… CONTINUE READING

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