Functional evidence for oxygen-sensitive voltage-gated potassium channels in human placental vasculature.

@article{Kiernan2010FunctionalEF,
  title={Functional evidence for oxygen-sensitive voltage-gated potassium channels in human placental vasculature.},
  author={M F Kiernan and Alexander C Barrie and J Szkolar and T. A. Mills and Mark Wareing},
  journal={Placenta},
  year={2010},
  volume={31 6},
  pages={553-5}
}
Hypoxic fetoplacental vasoconstriction (HFPV), involving voltage-gated potassium (K(V)) channels, has been suggested in human placenta; the identity of these channels remains unclear. Using wire myography, chorionic plate blood vessels were exposed to isoform-specific K(V) channel blockers. Dose-response curves (thromboxane mimetic U46619; 0.1-2000 nM) pre- and post-addition of K(V) channel modulator were analysed. Arterial U46619-induced contraction increased with margatoxin and stromatoxin-1… CONTINUE READING
9 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Similar Papers

Loading similar papers…