Functional evidence for altered activity of GABAergic receptors following chronic desipramine treatment in rats.

@article{Borsini1986FunctionalEF,
  title={Functional evidence for altered activity of GABAergic receptors following chronic desipramine treatment in rats.},
  author={Franco Borsini and Sandro Giuliani and Alberto Meli},
  journal={The Journal of pharmacy and pharmacology},
  year={1986},
  volume={38 12},
  pages={934-5}
}
The antinociceptive effect of subcutaneous 4,5,6,7-tetrahydroisoxazol[5,4-c]pyridin-3-ol (THIP) or (+/-)-baclofen, measured as reaction time of rats placed on a plate heated to 55 degrees C, was assessed after a single or the last repeated (18 consecutive days) dose (5 mg kg-1 once daily) of subcutaneous desipramine. Baclofen (10 mg kg-1)-induced antinociception was reduced by acute and unaffected by chronic desipramine treatment. On the contrary, THIP (20 mg kg-1)-induced antinociception was… CONTINUE READING