Functional evidence for a telomerase repressor gene on human chromosome 10p15.1

@article{Nishimoto2001FunctionalEF,
  title={Functional evidence for a telomerase repressor gene on human chromosome 10p15.1},
  author={Arata Nishimoto and Norimasa Miura and Izumi Horikawa and Hiroyuki Kugoh and Yoshinori Murakami and Setsuo Hirohashi and Hironaka Kawasaki and Adi F. Gazdar and Jerry W Shay and Jeffrey C. Barrett and Mitsuo Oshimura},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={828-835}
}
Based on the sites of frequent allelic loss in hepatocellular carcinoma, five normal human chromosomes (2, 4, 5, 10 and 16) were transferred individually into a telomerase-positive human hepatocellular carcinoma cell line, Li7HM, by microcell-mediated chromosome transfer (MMCT). Chromosome 10, but not the others, repressed telomerase activity immediately and stopped cell growth after 50 population doublings (PDs). Loss of the transferred 10p loci resulted in the emergence of revertant cells… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-8 of 8 references

J

  • Y Murakami, H Uejima, H Fukuhara, T Maruyama, M Oshimura, T. Sekiya
  • Hum. Genet., 45, 370 ± 373.
  • 2000

Hum

  • YS Cong, J Wen, S. Bacchetti
  • Mol. Genet., 8, 137 ± 142.
  • 1999

Mol

  • I Horikawa, M Oshimura, JC. Barrett
  • Carcinogen., 22, 65 ± 72.
  • 1998
2 Excerpts

Cancer Genet

  • N Miura, I Horikawa, +5 authors M. Oshimura
  • Cytogenet., 93, 56 ± 62.
  • 1997
1 Excerpt

Eur

  • OshimuraM, Barrett JC.
  • J. Cancer, 33, 710 ± 715.
  • 1997

Genes Chrom

  • AMJ Voesten, EH Bijleveld, A Westerveld, TJM. Hulsebos
  • Cancer, 20, 167 ± 172.
  • 1997

Nat

  • ES Dieken, EM Epner, S Fiering, REK Fournier, M. Groudine
  • Genet., 12, 174 ± 182.
  • 1996
1 Excerpt

Jpn

  • H Ohmura, H Tahara, +7 authors M. Oshimura
  • J. Cancer Res., 86, 899 ± 904.
  • 1995

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