Functional evidence for TCR-intrinsic specificity for MHCII

  • Heather L. Parrisha, Neha R. Deshpandea, Jelena Vasica, Michael S. Kuhnsa
  • Published 2016

Abstract

How T cells become restricted to binding antigenic peptides within class I or class II major histocompatibility complex molecules (pMHCI or pMHCII, respectively) via clonotypic T-cell receptors (TCRs) remains debated. During development, if TCR–pMHC interactions exceed an affinity threshold, a signal is generated that positively selects the thymocyte to… (More)

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