Functional evidence for TCR-intrinsic specificity for MHCII

  • Heather L. Parrisha, Neha R. Deshpandea, Jelena Vasica, Michael S. Kuhnsa
  • Published 2016


How T cells become restricted to binding antigenic peptides within class I or class II major histocompatibility complex molecules (pMHCI or pMHCII, respectively) via clonotypic T-cell receptors (TCRs) remains debated. During development, if TCR–pMHC interactions exceed an affinity threshold, a signal is generated that positively selects the thymocyte to… (More)

7 Figures and Tables


  • Presentations referencing similar topics