Functional eukaryotic nuclear localization signals are widespread in terminal proteins of bacteriophages.

@article{RedrejoRodrguez2012FunctionalEN,
  title={Functional eukaryotic nuclear localization signals are widespread in terminal proteins of bacteriophages.},
  author={Modesto Redrejo-Rodr{\'i}guez and Daniel Mu{\~n}oz-Esp{\'i}n and Isabel Holguera and Mario Menc{\'i}a and M. Salas},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 45},
  pages={
          18482-7
        }
}
A number of prokaryotic proteins have been shown to contain nuclear localization signals (NLSs), although its biological role remains sometimes unclear. Terminal proteins (TPs) of bacteriophages prime DNA replication and become covalently linked to the genome ends. We predicted NLSs within the TPs of bacteriophages from diverse families and hosts and, indeed, the TPs of Φ29, Nf, PRD1, Bam35, and Cp-1, out of seven TPs tested, were found to localize to the nucleus when expressed in mammalian… CONTINUE READING
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