Functional epigenomics identifies genes frequently silenced in prostate cancer.

@article{Lodygin2005FunctionalEI,
  title={Functional epigenomics identifies genes frequently silenced in prostate cancer.},
  author={Dimitri Lodygin and Alexey Epanchintsev and Antje Menssen and Joachim Diebold and Heiko Hermeking},
  journal={Cancer research},
  year={2005},
  volume={65 10},
  pages={4218-27}
}
In many cases, silencing of gene expression by CpG methylation is causally involved in carcinogenesis. Furthermore, cancer-specific CpG methylation may serve as a tumor marker. In order to identify candidate genes for inactivation by CpG methylation in prostate cancer, the prostate cancer cell lines LNCaP, PC3, and Du-145 were treated with 5-aza-2' deoxycytidine and trichostatin A, which leads to reversion of epigenetic silencing. By microarray analysis of 18,400 individual transcripts, several… CONTINUE READING
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