Functional endothelin ETB receptors on renal papillary tubules.

  title={Functional endothelin ETB receptors on renal papillary tubules.},
  author={Elizabeth A. Woodcock and Scott Land},
  journal={European journal of pharmacology},
  volume={247 1},
Addition of endothelin-1 or endothelin-3 to rat renal papillary tubules produced a dose-dependent inhibition of the cAMP response to vasopressin stimulation. The average EC50 values were 1.1 +/- 0.6 and 2.6 +/- 1.1 nM, respectively, indicating mediation by an endothelin ETB receptor. Phorbol myristate acetate (1 microM) also inhibited the vasopressin-cAMP response and this inhibition was not additive with that to endothelin, indicating that the endothelin inhibition is mediated by activation of… CONTINUE READING