Functional effects of single dose first- and second-generation antipsychotic administration in subjects with schizophrenia

@article{Lahti2005FunctionalEO,
  title={Functional effects of single dose first- and second-generation antipsychotic administration in subjects with schizophrenia},
  author={A. C. Lahti and Martin A. Weiler and Deborah R. Medoff and Carol A. Tamminga and Henry H. Holcomb},
  journal={Psychiatry Research: Neuroimaging},
  year={2005},
  volume={139},
  pages={19-30}
}
Using PET with (15)O water, we characterized the time course of functional brain changes following the acute administration of a first- and a second-generation antipsychotic. Volunteers with schizophrenia were scanned while drug-free (baseline) and after single dose administration of haloperidol (n=6) or olanzapine (n=6) during a time course adapted to their plasma kinetics. To obtain brain location information, we contrasted each post-drug scan to baseline-acquired scans. We plotted the… CONTINUE READING

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