Functional effects of periodic tryptophan substitutions in the alpha M4 transmembrane domain of the Torpedo californica nicotinic acetylcholine receptor.

@article{Tamamizu2000FunctionalEO,
  title={Functional effects of periodic tryptophan substitutions in the alpha M4 transmembrane domain of the Torpedo californica nicotinic acetylcholine receptor.},
  author={Shiori Tamamizu and Gisila R. Guzm{\'a}n and J. Carlos Santiago and Legier V. Rojas and Mark G. McNamee and Jos{\'e} Antonio Lasalde-Dominicci},
  journal={Biochemistry},
  year={2000},
  volume={39 16},
  pages={4666-73}
}
Previous amino acid substitutions at the M4 domain of the Torpedo californica and mouse acetylcholine receptor suggested that the location of the substitution relative to the membrane-lipid interface and perhaps to the ion pore can be critical to the channel gating mechanism [Lasalde, J. A., Tamamizu, S., Butler, D. H., Vibat, C. R. T., Hung, B., and… CONTINUE READING