Functional effects of nonsynonymous polymorphisms in the human TRPV1 gene.

@article{Xu2007FunctionalEO,
  title={Functional effects of nonsynonymous polymorphisms in the human TRPV1 gene.},
  author={Hongshi Xu and Wei Tian and Yi Fu and Terry T Oyama and Sharon Anderson and David M. Cohen},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={293 6},
  pages={F1865-76}
}
The prototypical member of the vanilloid-responsive-like subfamily of transient receptor potential (TRP) channels is TRPV1. TRPV1 mediates aspects of nociception and neurogenic inflammation; however, new roles are emerging in sensation of both luminal stretch and systemic tonicity. Although at least six nonsynonymous polymorphisms in the human TRPV1 gene have been identified, there has been no systematic investigation into their functional consequences. When heterologously expressed in HEK293… CONTINUE READING

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Activation of protein kinase C reverses capsaicin-induced F1874 SNPs IN HUMAN TRPV1 AJP-Renal Physiol

  • S Mandadi, M Numazaki, M Tominaga, MB Bhat, PJ Armati, BD. Roufogalis
  • Cell Calcium
  • 2007
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