Functional effects of neuromelanin and synthetic melanin in model systems

  title={Functional effects of neuromelanin and synthetic melanin in model systems},
  author={K. Double},
  journal={Journal of Neural Transmission},
  • K. Double
  • Published 2006
  • Biology, Medicine
  • Journal of Neural Transmission
  • Summary.The function of the dark polymer pigment neuromelanin found in catecholaminergic neurons of the human brain is not understood, especially as most published data are based upon a synthetic model melanin which differs structurally to the native pigment. Nevertheless human neuromelanin has been shown to efficiently bind transition metals such as iron, as well as other potentially toxic molecules. The pigment may have a protective function in the healthy brain by, for example, contributing… CONTINUE READING
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