Functional effects of cis-thymine glycol lesions on DNA synthesis in vitro.

@article{Clark1987FunctionalEO,
  title={Functional effects of cis-thymine glycol lesions on DNA synthesis in vitro.},
  author={J. Marshall Clark and G. Peter Beardsley},
  journal={Biochemistry},
  year={1987},
  volume={26 17},
  pages={5398-403}
}
Thymine glycol, a DNA lesion produced by ionizing radiation, has been introduced site specifically at high frequency into a synthetic oligonucleotide by chemical oxidation of the single thymine residue within the sequence. The lesion-containing template was then annealed to a complementary synthetic primer and used to study the effects of cis-thymine glycol… CONTINUE READING